This can be a complex clinical condition. Typically, diabetes would be an underlying cause that has resulted in either atypical fractures or deformities in the ankle or foot. The lower limb is most frequently affected. In Charcot foot, specialized expertise in assessment and treatment of the foot and ankle are needed to prevent the development of complications and amputation. In selected cases, a reconstruction of the foot and ankle can allow salvage of the foot and avoid an amputation or correct deformity.